Chemerin is a novel adipocyte-derived factor inducing insulin resistance in primary human skeletal muscle cells.

ABSTRACT:

Objective

Chemerin is an adipokine that affects adipogenesis and glucose homeostasis in adipocytes and increases with BMI in humans. This study was aimed at investigating the regulation of chemerin release and its effects on glucose metabolism in skeletal muscle cells.

Research design and methods

Human skeletal muscle cells were treated with chemerin to study insulin signaling, glucose uptake, and activation of stress kinases. The release of chemerin was analyzed from in vitro differentiated human adipocytes and adipose tissue explants from 27 lean and 26 obese patients.

Results

Human adipocytes express chemerin and chemokine-like receptor 1 (CMKLR1) differentiation dependently and secrete chemerin (15 ng/ml from 10(6) cells). This process is slightly but significantl

SUBMITTER: Sell H 

PROVIDER: S-EPMC2780878 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature