Common genetic determinants of glucose homeostasis in healthy children: the European Youth Heart Study.

ABSTRACT:

Objective

The goal of this study was to investigate whether the effects of common genetic variants associated with fasting glucose in adults are detectable in healthy children.

Research design and methods

Single nucleotide polymorphisms in MTNR1B (rs10830963), G6PC2 (rs560887), and GCK (rs4607517) were genotyped in 2,025 healthy European children aged 9-11 and 14-16 years. Associations with fasting glucose, insulin, homeostasis model assessment (HOMA)-insulin resistance (IR) and HOMA-B were investigated along with those observed for type 2 diabetes variants available in this study (CDKN2A/B, IGF2BP2, CDKAL1, SLC30A8, HHEX-IDE, and Chr 11p12).

Results

Strongest associations were observed for G6PC2 and MTNR1B, with mean fasting glucose levels (95% CI) being 0.084 (0.06-

SUBMITTER: Kelliny C 

PROVIDER: S-EPMC2780884 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature