Protective effects of human iPS-derived retinal pigment epithelium cell transplantation in the retinal dystrophic rat.

ABSTRACT: Transformation of somatic cells with a set of embryonic transcription factors produces cells with the pluripotent properties of embryonic stem cells (ESCs). These induced pluripotent stem (iPS) cells have the potential to differentiate into any cell type, making them a potential source from which to produce cells as a therapeutic platform for the treatment of a wide range of diseases. In many forms of human retinal disease, including age-related macular degeneration (AMD), the underlying pathogenesis resides within the support cells of the retina, the retinal pigment epithelium (RPE). As a monolayer of cells critical to photoreceptor function and survival, the RPE is an ideally accessible target for cellular therapy. Here we report the differentiation of human iPS cells into RPE. We found

SUBMITTER: Carr AJ 

PROVIDER: S-EPMC2780911 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature