Surgical stress-induced immune cell redistribution profiles predict short-term and long-term postsurgical recovery. A prospective study.

ABSTRACT:

Background

The experience of undergoing surgery is known to induce a short-term, fight-or-flight physiological stress response. As an optimum immune response at the site of surgery would enhance tissue repair, we examined surgical stress-induced immune cell redistribution profiles as predictors, and potential mediators, of short and long-term postoperative recovery. We tested the a priori hypothesis that predefined adaptive immune cell redistribution profiles observed during surgery will predict enhanced postoperative recovery.

Methods

This prospective longitudinal study involved fifty-seven patients undergoing meniscectomy. Knee function was assessed preoperatively and at one, three, eight, sixteen, twenty-four, and forty-eight weeks postoperatively with use of the clinical

SUBMITTER: Rosenberger PH 

PROVIDER: S-EPMC2780920 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature