A study in entire chromosomes of violations of the intra-strand parity of complementary nucleotides (Chargaff's second parity rule).

ABSTRACT: Chargaff's rule of intra-strand parity (ISP) between complementary mono/oligonucleotides in chromosomes is well established in the scientific literature. Although a large numbers of papers have been published citing works and discussions on ISP in the genomic era, scientists are yet to find all the factors responsible for such a universal phenomenon in the chromosomes. In the present work, we have tried to address the issue from a new perspective, which is a parallel feature to ISP. The compositional abundance values of mono/oligonucleotides were determined in all non-overlapping sub-chromosomal regions of specific size. Also the frequency distributions of the mono/oligonucleotides among the regions were compared using the Kolmogorov-Smirnov test. Interestingly, the frequency distributions

SUBMITTER: Powdel BR 

PROVIDER: S-EPMC2780954 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature