Expression profiling of the ovarian surface kinome reveals candidate genes for early neoplastic changes.

ABSTRACT:

Objectives

We tested the hypothesis that co-coordinated up-regulation or down-regulation of several ovarian cell surface kinases may provide clues for better understanding of the disease and help in rational design of therapeutic targets.

Study design

We compared the expression signature of 69 surface kinases in normal ovarian surface epithelial cells (OSE), with OSE from patients at high risk and with ovarian cancer.

Results

Seven surface kinases, ALK, EPHA5, EPHB1, ERBB4, INSRR, PTK, and TGFbetaR1 displayed a distinctive linear trend in expression from normal, highrisk, and malignant epithelium. We confirmed these results using semiquantitative reverse transcription-polymerase chain reaction and tissue array of 202 ovarian cancer samples. A strong correlate was show

SUBMITTER: Pejovic T 

PROVIDER: S-EPMC2781076 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature