Adenosine-to-inosine genetic recoding is required in the adult stage nervous system for coordinated behavior in Drosophila.

ABSTRACT: Adenosine deaminases acting on RNA (ADARs) catalyze the deamination of adenosine to inosine in double-stranded RNA templates, a process known as RNA editing. In Drosophila, multiple ADAR isoforms are generated from a single locus (dAdar) via post-transcriptional modifications. Collectively, these isoforms act to edit a wide range of transcripts involved in neuronal signaling, as well as the precursors of endogenous small interfering RNAs. The phenotypic consequences of a loss of dADAR activity have been well characterized and consist of profound behavioral defects manifested at the adult stage, including extreme uncoordination, seizures, and temperature-sensitive paralysis. However, the spatio-temporal requirements of adenosine to inosine editing for correct behavior are unclear. Using tra

SUBMITTER: Jepson JE 

PROVIDER: S-EPMC2781535 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature