A proteomic view of an important human pathogen--towards the quantification of the entire Staphylococcus aureus proteome.

ABSTRACT: The genome sequence is the "blue-print of life," but proteomics provides the link to the actual physiology of living cells. Because of their low complexity bacteria are excellent model systems to identify the entire protein assembly of a living organism. Here we show that the majority of proteins expressed in growing and non-growing cells of the human pathogen Staphylococcus aureus can be identified and even quantified by a metabolic labeling proteomic approach. S. aureus has been selected as model for this proteomic study, because it poses a major risk to our health care system by combining high pathogenicity with an increasing frequency of multiple antibiotic resistance, thus requiring the development of new anti-staphylococcal therapy strategies. Since such strategies will likely have t

SUBMITTER: Becher D 

PROVIDER: S-EPMC2781549 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature