Ror2 receptor requires tyrosine kinase activity to mediate Wnt5A signaling.

ABSTRACT: The Wnts include a large family of secreted proteins that serve as important signals during embryonic development and adult homeostasis. In the most well understood Wnt signaling pathway, Wnt binding to Frizzled and low density lipoprotein receptor-related protein induces beta-catenin protein stabilization and entry into the nucleus, resulting in changes in target gene transcription. Emerging evidence suggests that Wnt5a can inhibit Wnt/beta-catenin signaling through interaction with the receptor Ror2. The Ror2 protein belongs to the receptor tyrosine kinase superfamily and contains several recognizable structural motifs. However, limited information is available regarding which specific domains are required for the inhibitory signaling activity of Wnt5a. Through mutation and deletion anal

SUBMITTER: Mikels A 

PROVIDER: S-EPMC2781572 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature