Wnt5 is required for notochord cell intercalation in the ascidian Halocynthia roretzi.

ABSTRACT:

Background information

In the embryos of various animals, the body elongates after gastrulation by morphogenetic movements involving convergent extension. The Wnt/PCP (planar cell polarity) pathway plays roles in this process, particularly mediolateral polarization and intercalation of the embryonic cells. In ascidians, several factors in this pathway, including Wnt5, have been identified and found to be involved in the intercalation process of notochord cells.

Results

In the present study, the role of the Wnt5 genes, Hr-Wnt5alpha (Halocynthia roretzi Wnt5alpha) and Hr-Wnt5beta, in convergent extension was investigated in the ascidian H. roretzi by injecting antisense oligonucleotides and mRNAs into single precursor blastomeres of various tissues, including notochord, at the

SUBMITTER: Niwano T 

PROVIDER: S-EPMC2782306 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature