Geminin is partially localized to the centrosome and plays a role in proper centrosome duplication.

ABSTRACT:

Background information

Centrosome duplication normally parallels with DNA replication and is responsible for correct segregation of replicated DNA into the daughter cells. Although geminin interacts with Cdt1 to prevent loading of MCMs (minichromosome maintenance proteins) on to the replication origins, inactivation of geminin nevertheless causes centrosome over-duplication in addition to the re-replication of the genome, suggesting that geminin may play a role in centrosome duplication. However, the exact mechanism by which loss of geminin affects centrosomal duplication remains unclear and the possible direct interaction of geminin with centrosomal-localized proteins is still unidentified.

Results

We report in the present study that geminin is physically localized to the c

SUBMITTER: Lu F 

PROVIDER: S-EPMC2782310 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature