Conformational Analysis of Triazine Dendrimers: Using NMR Spectroscopy To Probe the Choreography of a Dendrimer's Dance.

ABSTRACT: One-dimensional (1D) and two-dimensional (2D) NMR studies are used to probe the conformation of a melamine dendrimer bearing unique NMR signals from the core to the periphery. Four conceptual anchors for dendrimer conformation emerge from these experiments. First, changes in isomer populations observed by (1)H NMR reveal the onset of globular structure. Second, NOE complexity emerges with globular structure: variable temperature NOESY studies show that the peripheral groups, BOC-protected aliphatic amines, fold back into the globular core of the macromolecule at 75 degrees C in DMSO-d(6). Third, variable temperature coefficients measured for NH protons suggest that solvent is largely excluded from the interior of the dendrimer: the carbamate NH groups of the periphery are most sensitive to

SUBMITTER: Moreno KX 

PROVIDER: S-EPMC2782416 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature