Caged ceramide 1-phosphate analogues: synthesis and properties.

ABSTRACT: Sphingolipid phosphate analogues bearing 7-(diethylamino)coumarin (DECM) and 4-bromo-5-hydroxy-2-nitrobenzhydryl (BHNB) groups in a photolabile ester bond were synthesized. The ability of the "caged" ceramide 1-phosphate analogues to release the bioactive parent molecule upon irradiation at 400-500 nm was demonstrated by stimulation of macrophage cell proliferation.

SUBMITTER: Lankalapalli RS 

PROVIDER: S-EPMC2782442 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature