Comprehensive polymorphism survey elucidates population structure of Saccharomyces cerevisiae.

ABSTRACT: Comprehensive identification of polymorphisms among individuals within a species is essential both for studying the genetic basis of phenotypic differences and for elucidating the evolutionary history of the species. Large-scale polymorphism surveys have recently been reported for human, mouse and Arabidopsis thaliana. Here we report a nucleotide-level survey of genomic variation in a diverse collection of 63 Saccharomyces cerevisiae strains sampled from different ecological niches (beer, bread, vineyards, immunocompromised individuals, various fermentations and nature) and from locations on different continents. We hybridized genomic DNA from each strain to whole-genome tiling microarrays and detected 1.89 million single nucleotide polymorphisms, which were grouped into 101,343 distinct s

SUBMITTER: Schacherer J 

PROVIDER: S-EPMC2782482 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature