Lipid and glucose alterations in HIV-infected children beginning or changing antiretroviral therapy.

ABSTRACT:

Objective

The objective of this study was to describe lipid profiles and glucose homeostasis in HIV-positive children after initiating or changing antiretroviral therapy and their associations with viral, immune, antiretroviral therapy, and growth factor parameters.

Methods

Ninety-seven prepubertal HIV-positive children aged 1 month to <13 years were observed for 48 weeks after beginning or changing antiretroviral therapy. Fasting lipid panels, serum glucose, insulin, insulin-like growth factor-1 and binding proteins-1 and -3, plasma viral load, and CD4% were measured. Each child was matched on age, gender, and race/ethnicity to children from the National Health and Nutrition Examination Survey, used to give z scores for each child's lipid values. Multivariate regression was

SUBMITTER: Chantry CJ 

PROVIDER: S-EPMC2782494 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature