Enantio- and diastereoselective intermolecular Stetter reaction of glyoxamide and alkylidene ketoamides.

ABSTRACT: A triazolinylidene carbene catalyzed intermolecular Stetter reaction of glyoxamide and alkylidene ketoamides has been developed. 1,4-Dicarbonyl products are afforded in good to excellent yields, enantioselectivities, and diastereoselectivities. Further derivatization of the products affords useful intermediates for organic synthesis.

SUBMITTER: Liu Q 

PROVIDER: S-EPMC2782595 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature