Subsets of very low risk Wilms tumor show distinctive gene expression, histologic, and clinical features.

ABSTRACT:

Purpose

Recent studies suggest that children <24 months with stage I favorable histology Wilms tumors <550 g [very low risk Wilms tumors (VLRWT)] have an excellent prognosis when treated with nephrectomy only, without adjuvant chemotherapy. The identification of risk categories within VLRWT may enable refinement of their definition and optimization of their therapy.

Experimental design

To define biologically distinct subsets, global gene expression analysis was done on 39 VLRWT that passed all quality-control parameters and the clusters identified were validated in an independent set of 11 VLRWT. Validation of select differentially expressed genes was done with immunohistochemistry on a tissue microarray from 20 of 39 tumors. Loss of heterozygosity (LOH) for 11p15, 1p, and 1

SUBMITTER: Sredni ST 

PROVIDER: S-EPMC2782600 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature