Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populations.

ABSTRACT:

Background

The ECG QT interval is associated with risk of sudden cardiac death (SCD). A previous genome-wide association study demonstrated that allelic variants (rs10494366 and rs4657139) in the nitric oxide synthase 1 adaptor protein (NOS1AP), which encodes a carboxy-terminal PDZ ligand of neuronal nitric oxide synthase, are associated with the QT interval in white adults. The present analysis was conducted to validate the association between NOS1AP variants and the QT interval and to examine the association with SCD in a combined population of 19 295 black and white adults from the Atherosclerosis Risk In Communities Study and the Cardiovascular Health Study.

Methods and results

We examined 19 tagging single-nucleotide polymorphisms in the genomic blocks containing rs1049

SUBMITTER: Kao WH 

PROVIDER: S-EPMC2782762 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature