Phylogenetic Profiles Reveal Structural and Functional Determinants of Lipid-binding.

ABSTRACT: One of the major challenges in the genomic era is annotating structure/function to the vast quantities of sequence information now available. Indeed, most of the protein sequence database lacks comprehensive annotation, even when experimental evidence exists. Further, within structurally resolved and functionally annotated protein domains, additional functionalities contained in these domains are not apparent. To add further complication, small changes in the amino-acid sequence can lead to profound changes in both structure and function, underscoring the need for rapid and reliable methods to analyze these types of data. Phylogenetic profiles provide a quantitative method that can relate the structural and functional properties of proteins, as well as their evolutionary relationships. Usi

SUBMITTER: Hong Y 

PROVIDER: S-EPMC2782862 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature