SitesIdentify: a protein functional site prediction tool.

ABSTRACT:

Background

The rate of protein structures being deposited in the Protein Data Bank surpasses the capacity to experimentally characterise them and therefore computational methods to analyse these structures have become increasingly important. Identifying the region of the protein most likely to be involved in function is useful in order to gain information about its potential role. There are many available approaches to predict functional site, but many are not made available via a publicly-accessible application.

Results

Here we present a functional site prediction tool (SitesIdentify), based on combining sequence conservation information with geometry-based cleft identification, that is freely available via a web-server. We have shown that SitesIdentify compares favourably

SUBMITTER: Bray T 

PROVIDER: S-EPMC2783165 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature