Snail promotes CXCR2 ligand-dependent tumor progression in non-small cell lung carcinoma.

ABSTRACT:

Purpose

As a transcriptional repressor of E-cadherin, Snail has predominantly been associated with epithelial-mesenchymal transition, invasion, and metastasis. However, other important Snail-dependent malignant phenotypes have not been fully explored. Here, we investigate the contributions of Snail to the progression of non-small cell lung cancer (NSCLC).

Experimental design

Immunohistochemistry was done to quantify and localize Snail in human lung cancer tissues, and tissue microarray analysis was used to correlate these findings with survival. NSCLC cell lines gene-modified to stably overexpress Snail were evaluated in vivo in two severe combined immunodeficiency murine tumor models. Differential gene expression between Snail-overexpressing and control cell lines was evalu

SUBMITTER: Yanagawa J 

PROVIDER: S-EPMC2783274 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature