Expression profiles of schizophrenia susceptibility genes during human prefrontal cortical development.

ABSTRACT:

Background

Disruption in normal development of the human prefrontal cortex (PFC) may lead to cognitive dysfunction that manifests in individuals with schizophrenia. We sought to identify genes associated with age that are implicated in schizophrenia.

Methods

We generated genome-wide expression profiles for the PFCs of humans ranging in age from 1 month to 49 years using the Affymetrix HG-U133 plus 2.0 microarrays (54 675 transcripts). Based on the criteria of significance (false discovery rate [FDR]-adjusted q < 0.001 and r(2) > 0.6), we identified the genes associated with age in the PFC. We then performed functional annotation analyses of age-associated genes using the Gene Ontology and the Genetic Association Database (GAD).

Results

We found robust age-dependent ch

SUBMITTER: Choi KH 

PROVIDER: S-EPMC2783436 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature