Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial.

ABSTRACT:

Objective

The aim of this study was to evaluate the safety and efficacy of black cohosh and red clover compared with placebo for the relief of menopausal vasomotor symptoms.

Methods

This study was a randomized, four-arm, double-blind clinical trial of standardized black cohosh, red clover, placebo, and 0.625 mg conjugated equine estrogens plus 2.5 mg medroxyprogesterone acetate (CEE/MPA; n = 89). Primary outcome measures were reduction in vasomotor symptoms (hot flashes and night sweats) by black cohosh and red clover compared with placebo; secondary outcomes included safety evaluation, reduction of somatic symptoms, relief of sexual dysfunction, and overall improvement in quality of life.

Results

Reductions in number of vasomotor symptoms after a 12-month interventio

SUBMITTER: Geller SE 

PROVIDER: S-EPMC2783540 | biostudies-literature | 2009 Nov-Dec

REPOSITORIES: biostudies-literature