Reducing the risk of major elective surgery: randomised controlled trial of preoperative optimisation of oxygen delivery.

ABSTRACT:

Objectives

To determine whether preoperative optimisation of oxygen delivery improves outcome after major elective surgery, and to determine whether the inotropes, adrenaline and dopexamine, used to enhance oxygen delivery influence outcome.

Design

Randomised controlled trial with double blinding between inotrope groups.

Setting

York District Hospital, England.

Subjects

138 patients undergoing major elective surgery who were at risk of developing postoperative complications either because of the surgery or the presence of coexistent medical conditions.

Interventions

Patients were randomised into three groups. Two groups received invasive haemodynamic monitoring, fluid, and either adrenaline or dopexamine to increase oxygen delivery. Inotropic support was

SUBMITTER: Wilson J 

PROVIDER: S-EPMC27840 | biostudies-literature | 1999 Apr

REPOSITORIES: biostudies-literature