Exposure to traffic-related particles and endotoxin during infancy is associated with wheezing at age 3 years.

ABSTRACT:

Rationale

Murine models demonstrate a synergistic production of reactive oxygen species on coexposure to diesel exhaust particles and endotoxin.

Objectives

It was hypothesized that coexposure to traffic-related particles and endotoxin would have an additive effect on persistent wheezing during early childhood.

Methods

Persistent wheezing at age 36 months was assessed in the Cincinnati Childhood Allergy and Air Pollution Study, a high-risk birth cohort. A time-weighted average exposure to traffic-related particles was determined by applying a land-use regression model to the homes, day cares, and other locations where children spent time from birth through age 36 months. Indoor levels of endotoxin were measured from dust samples collected before age 12 months. The rela

SUBMITTER: Ryan PH 

PROVIDER: S-EPMC2784413 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature