Bone marrow stromal cells attenuate lung injury in a murine model of neonatal chronic lung disease.

ABSTRACT:

Rationale

Neonatal chronic lung disease, known as bronchopulmonary dysplasia (BPD), remains a serious complication of prematurity despite advances in the treatment of extremely low birth weight infants.

Objectives

Given the reported protective actions of bone marrow stromal cells (BMSCs; mesenchymal stem cells) in models of lung and cardiovascular injury, we tested their therapeutic potential in a murine model of BPD.

Methods

Neonatal mice exposed to hyperoxia (75% O(2)) were injected intravenously on Day 4 with either BMSCs or BMSC-conditioned media (CM) and assessed on Day 14 for lung morphometry, vascular changes associated with pulmonary hypertension, and lung cytokine profile.

Measurements and main results

Injection of BMSCs but not pulmonary artery smooth

SUBMITTER: Aslam M 

PROVIDER: S-EPMC2784417 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature