Expression of complement system components during aging and amyloid deposition in APP transgenic mice.

ABSTRACT:

Background

A causal role of the complement system in Alzheimer's disease pathogenesis has been postulated based on the identification of different activated components up to the membrane attack complex at amyloid plaques in brain. However, histological studies of amyloid plaque bearing APP transgenic mice provided only evidence for an activation of the early parts of the complement cascade. To better understand the contribution of normal aging and amyloid deposition to the increase in complement activation we performed a detailed characterization of the expression of the major mouse complement components.

Methods

APP23 mice expressing human APP751 with the Swedish double mutation as well as C57BL/6 mice were used at different ages. mRNA was quantified by Realtime PCR and the

SUBMITTER: Reichwald J 

PROVIDER: S-EPMC2784442 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature