Induced ER chaperones regulate a receptor-like kinase to mediate antiviral innate immune response in plants.

ABSTRACT: Mounting an effective innate immune response against pathogens requires the rapid and global reprogramming of host cellular processes. Here we employed complementary proteomic methods to identify differentially regulated proteins early during a plant's defense response. Besides defense-related proteins, constituents of the largest category of upregulated proteins were cytoplasmic- and ER-residing molecular chaperones. Investigating the significance of upregulated ER chaperones, we find that silencing of ER-resident protein disulfide isomerases NbERp57 and NbP5 and the calreticulins NbCRT2 and NbCRT3 led to partial loss of N immune receptor-mediated defense against Tobacco mosaic virus (TMV). Furthermore, NbCRT2 and NbCRT3 were required for the expression of a previously uncharacterized ind

SUBMITTER: Caplan JL 

PROVIDER: S-EPMC2784700 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature