Evidence of recombination in Hepatitis C Virus populations infecting a hemophiliac patient.

ABSTRACT:

Background/aim

Hepatitis C virus (HCV) infection is an important cause of morbidity and mortality in patients affected by hereditary bleeding disorders. HCV, as others RNA virus, exploit all possible mechanisms of genetic variation to ensure their survival, such as recombination and mutation. In order to gain insight into the genetic variability of HCV virus strains circulating in hemophiliac patients, we have performed a phylogenetic analysis of HCV strains isolated from 10 patients with this kind of pathology.

Methods

Putative recombinant sequence was identified with the use of GARD program. Statistical support for the presence of a recombination event was done by the use of LARD program.

Results

A new intragenotypic recombinant strain (1b/1a) was detected in 1 out

SUBMITTER: Moreno P 

PROVIDER: S-EPMC2784780 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature