The choroid plexus response to a repeated peripheral inflammatory stimulus.

ABSTRACT:

Background

Chronic systemic inflammation triggers alterations in the central nervous system that may relate to the underlying inflammatory component reported in neurodegenerative disorders such as multiple sclerosis and Alzheimer's disease. However, it is far from being understood whether and how peripheral inflammation contributes to induce brain inflammatory response in such illnesses. As part of the barriers that separate the blood from the brain, the choroid plexus conveys inflammatory immune signals into the brain, largely through alterations in the composition of the cerebrospinal fluid.

Results

In the present study we investigated the mouse choroid plexus gene expression profile, using microarray analyses, in response to a repeated inflammatory stimulus induced by the

SUBMITTER: Marques F 

PROVIDER: S-EPMC2784788 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature