Ontology highlight
ABSTRACT:
SUBMITTER: Hensley SE
PROVIDER: S-EPMC2784927 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20091001 5953
Rapid antigenic evolution in the influenza A virus hemagglutinin precludes effective vaccination with existing vaccines. To understand this phenomenon, we passaged virus in mice immunized with influenza vaccine. Neutralizing antibodies selected mutants with single-amino acid hemagglutinin substitutions that increased virus binding to cell surface glycan receptors. Passaging these high-avidity binding mutants in naïve mice, but not immune mice, selected for additional hemagglutinin substitutions ...[more]