Memory performance is related to amyloid and tau pathology in the hippocampus.

ABSTRACT:

Objective

To determine the relation of amyloid and tau pathology in the hippocampal formation to decline in memory and other cognitive functions in Alzheimer's disease (AD).

Methods

Regression models were used to relate semiquantitative measurements of amyloid plaques, neurofibrillary tangles (NFTs) and neuropil threads (NTs) at autopsy with antemortem performance in memory, abstract/visuospatial and language domains in two independent samples (n = 41, n = 66) that had repeated neuropsychological measurements before death.

Results

In both groups, the number of NFTs in the entorhinal cortex, subiculum and CA1 region was inversely associated with memory performance at the last visit before death. However, the number of amyloid plaques and NTs in the entorhinal cortex wa

SUBMITTER: Reitz C 

PROVIDER: S-EPMC2785022 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature