Tetrahydrobiopterin in the prevention of hypertonia in hypoxic fetal brain.

ABSTRACT:

Objective

Tetrahydrobiopterin (BH(4)) deficiency is a cause of dystonia at birth. We hypothesized that BH(4) is a developmental factor determining vulnerability of the immature fetal brain to hypoxic-ischemic injury and subsequent motor deficits in newborns.

Methods

Pregnant rabbits were subjected to 40-minute uterine ischemia, and fetal brains were investigated for global and focal changes in BH(4). Newborn kits were assessed by neurobehavioral tests following vehicle and sepiapterin (BH(4) analog) treatment of dams.

Results

Naive fetal brains at 70% gestation (E22) were severely deficient for BH(4) compared with maternal and other fetal tissues. BH(4) concentration rapidly increased normally in the perinatal period, with the highest concentrations found in the thala

SUBMITTER: Vasquez-Vivar J 

PROVIDER: S-EPMC2785106 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature