The miR200 family of microRNAs regulates WAVE3-dependent cancer cell invasion.

ABSTRACT: MicroRNAs are small non-coding RNAs that are directly involved in the regulation of gene expression by either translational repression or degradation of target mRNAs. Because of the high level of conservation of the target motifs, known as seed sequences, within the 3'-untranslated regions, a single microRNA can regulate numerous target genes simultaneously, making this class of RNAs a powerful regulator of gene expression. The miR200 family of microRNAs has recently been shown to regulate the process of epithelial to mesenchymal transition during tumor progression and metastasis. Here, we report that the expression of WAVE3, an actin cytoskeleton remodeling and metastasis promoter protein, is regulated by miR200 microRNAs. We show a clear inverse correlation between expression levels of W

SUBMITTER: Sossey-Alaoui K 

PROVIDER: S-EPMC2785142 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature