Comparative expression profiling reveals an essential role for raldh2 in epimorphic regeneration.

ABSTRACT: Zebrafish have the remarkable ability to regenerate body parts including the heart and fins by a process referred to as epimorphic regeneration. Recent studies have illustrated that similar to adult zebrafish, early life stage larvae also possess the ability to regenerate the caudal fin. A comparative microarray analysis was used to determine the degree of conservation in gene expression among the regenerating adult caudal fin, adult heart, and larval fin. Results indicate that these tissues respond to amputation/injury with strikingly similar genomic responses. Comparative analysis revealed raldh2, a rate-limiting enzyme for the synthesis of retinoic acid, as one of the most highly induced genes across the three regeneration platforms. In situ localization and functional studies indicate

SUBMITTER: Mathew LK 

PROVIDER: S-EPMC2785206 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature