Genome reannotation of Escherichia coli CFT073 with new insights into virulence.

ABSTRACT:

Background

As one of human pathogens, the genome of Uropathogenic Escherichia coli strain CFT073 was sequenced and published in 2002, which was significant in pathogenetic bacterial genomics research. However, the current RefSeq annotation of this pathogen is now outdated to some degree, due to missing or misannotation of some essential genes associated with its virulence. We carried out a systematic reannotation by combining automated annotation tools with manual efforts to provide a comprehensive understanding of virulence for the CFT073 genome.

Results

The reannotation excluded 608 coding sequences from the RefSeq annotation. Meanwhile, a total of 299 coding sequences were newly added, about one third of them are found in genomic island (GI) regions while more than one fi

SUBMITTER: Luo C 

PROVIDER: S-EPMC2785843 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature