Cag3 is a novel essential component of the Helicobacter pylori Cag type IV secretion system outer membrane subcomplex.

ABSTRACT: Helicobacter pylori strains harboring the cag pathogenicity island (PAI) have been associated with more severe gastric disease in infected humans. The cag PAI encodes a type IV secretion (T4S) system required for CagA translocation into host cells as well as induction of proinflammatory cytokines, such as interleukin-8 (IL-8). cag PAI genes sharing sequence similarity with T4S components from other bacteria are essential for Cag T4S function. Other cag PAI-encoded genes are also essential for Cag T4S, but lack of sequence-based or structural similarity with genes in existing databases has precluded a functional assignment for the encoded proteins. We have studied the role of one such protein, Cag3 (HP0522), in Cag T4S and determined Cag3 subcellular localization and protein interactions. C

SUBMITTER: Pinto-Santini DM 

PROVIDER: S-EPMC2786551 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature