Poxvirus proteomics and virus-host protein interactions.

ABSTRACT: Studies of the functional proteins encoded by the poxvirus genome provide information about the composition of the virus as well as individual virus-virus protein and virus-host protein interactions, which provides insight into viral pathogenesis and drug discovery. Widely used proteomic techniques to identify and characterize specific protein-protein interactions include yeast two-hybrid studies and coimmunoprecipitations. Recently, various mass spectrometry techniques have been employed to identify viral protein components of larger complexes. These methods, combined with structural studies, can provide new information about the putative functions of viral proteins as well as insights into virus-host interaction dynamics. For viral proteins of unknown function, identification of either v

SUBMITTER: Van Vliet K 

PROVIDER: S-EPMC2786582 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature