Evaluation of hepatitis C virus core antigen assays in detecting recombinant viral antigens of various genotypes.

ABSTRACT: A single substitution within the hepatitis C virus core antigen sequence, A48T, which is observed in approximately 30% of individuals infected with genotype 2a virus, reduces the sensitivity of a commonly used chemiluminescence enzyme immunoassay. Quantitation of the antigen is improved by using a distinct anticore antibody with a different epitope.

SUBMITTER: Saeed M 

PROVIDER: S-EPMC2786616 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature