Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN response.

ABSTRACT: African green monkeys (AGMs) infected with the AGM type of SIV (SIVagm) do not develop chronic immune activation and AIDS, despite viral loads similar to those detected in humans infected with HIV-1 and rhesus macaques (RMs) infected with the RM type of SIV (SIVmac). Because chronic immune activation drives progressive CD4+ T cell depletion and immune cell dysfunctions, factors that characterize disease progression, we sought to understand the molecular basis of this AGM phenotype. To this end, we longitudinally assessed the gene expression profiles of blood- and lymph node-derived CD4+ cells from AGMs and RMs in response to SIVagm and SIVmac infection, respectively, using a genomic microarray platform. The molecular signature of acute infection was characterized, in both species, by stron

SUBMITTER: Jacquelin B 

PROVIDER: S-EPMC2786805 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature