PI3 kinase signals BCR-dependent mature B cell survival.

ABSTRACT: Previous work has shown that mature B cells depend upon survival signals delivered to the cells by their antigen receptor (BCR). To identify the molecular nature of this survival signal, we have developed a genetic approach in which ablation of the BCR is combined with the activation of specific, BCR dependent signaling cascades in mature B cells in vivo. Using this system, we provide evidence that the survival of BCR deficient mature B cells can be rescued by a single signaling pathway downstream of the BCR, namely PI3K signaling, with the FOXO1 transcription factor playing a central role.

SUBMITTER: Srinivasan L 

PROVIDER: S-EPMC2787092 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature