Ontology highlight
ABSTRACT:
SUBMITTER: Wu H
PROVIDER: S-EPMC2787125 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Wu Haiyan H Shekar S Chandra SC Flinn Rory J RJ El-Sibai Mirvat M Jaiswal Bijay S BS Sen K Ilker KI Janakiraman Vasantharajan V Seshagiri Somasekar S Gerfen Gary J GJ Girvin Mark E ME Backer Jonathan M JM
Proceedings of the National Academy of Sciences of the United States of America 20091113 48
We previously proposed a model of Class IA PI3K regulation in which p85 inhibition of p110alpha requires (i) an inhibitory contact between the p85 nSH2 domain and the p110alpha helical domain, and (ii) a contact between the p85 nSH2 and iSH2 domains that orients the nSH2 so as to inhibit p110alpha. We proposed that oncogenic truncations of p85 fail to inhibit p110 due to a loss of the iSH2-nSH2 contact. However, we now find that within the context of a minimal regulatory fragment of p85 (the nSH ...[more]