FAS promoter polymorphism: outcome of childhood acute myeloid leukemia. A children's oncology group report.

ABSTRACT:

Purpose

FAS is a cell surface receptor involved in apoptotic signal transmission. Deregulation of this pathway results in down-regulation of apoptosis and subsequent persistence of a malignant clone. A single nucleotide polymorphism resulting in guanine-to-adenine transition in the FAS promoter region (position -1377) is thought to reduce stimulatory protein 1 transcription factor binding and decrease FAS expression. Previous work has shown increased risk of developing acute myeloid leukemia (AML) in adult patients with a variant allele at this site. The same authors have shown that the presence of an adenine residue rather than a guanine residue at -1,377 bp significantly attenuates transcription factor stimulatory protein 1 binding and may contribute to a reduction in FAS express

SUBMITTER: Mehta PA 

PROVIDER: S-EPMC2787450 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature