Ontology highlight
ABSTRACT:
SUBMITTER: Lu BC
PROVIDER: S-EPMC2787691 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Nature genetics 20091108 12
Glial cell line-derived neurotrophic factor signaling through the Ret receptor tyrosine kinase is crucial for ureteric bud branching morphogenesis during kidney development, yet few of the downstream genes are known. Here we show that the ETS transcription factors Etv4 and Etv5 are positively regulated by Ret signaling in the ureteric bud tips. Mice lacking both Etv4 alleles and one Etv5 allele show either renal agenesis or severe hypodysplasia, whereas kidney development fails completely in dou ...[more]