Role of alveolar epithelial early growth response-1 (Egr-1) in CD8+ T cell-mediated lung injury.

ABSTRACT: Influenza infection of the distal airways results in severe lung injury, a considerable portion of which is immunopathologic and attributable to the host responses. We have used a mouse model to specifically investigate the role of antiviral CD8(+) T cells in this injury, and have found that the critical effector molecule is TNF-alpha expressed by the T cells upon antigen recognition. Interestingly, the immunopathology which ensues is characterized by significant accumulation of host inflammatory cells, recruited by chemokines expressed by the target alveolar epithelial cells. In this study we analyzed the mechanisms involved in the induction of epithelial chemokine expression triggered by antigen-specific CD8(+) T cell recognition, and demonstrate that the early growth response-1 (Egr-1)

SUBMITTER: Ramana CV 

PROVIDER: S-EPMC2787734 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature