Low-dose aspirin and medical record-confirmed age-related macular degeneration in a randomized trial of women.

ABSTRACT:

Objective

To test whether alternate-day low-dose aspirin affects incidence of age-related macular degeneration (AMD) in a large-scale randomized trial of women.

Design

Randomized, double-masked, placebo-controlled trial.

Participants

Thirty-nine thousand eight hundred seventy-six healthy female health professionals aged 45 years or older.

Intervention

Participants were assigned randomly to receive either 100 mg aspirin on alternate days or placebo and were followed up for the presence of AMD for an average of 10 years.

Main outcome measures

Incident AMD responsible for a reduction in best-corrected visual acuity to 20/30 or worse based on self-report confirmed by medical record review.

Results

After 10 years of treatment and follow-up, there were

SUBMITTER: Christen WG 

PROVIDER: S-EPMC2787838 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature