High-throughput screening identifies two classes of antibiotics as radioprotectors: tetracyclines and fluoroquinolones.

ABSTRACT:

Purpose

Discovery of agents that protect or mitigate normal tissue from radiation injury during radiotherapy, accidents, or terrorist attacks is of importance. Specifically, bone marrow insufficiency, with possible infection due to immunosuppression, can occur after total body irradiation (TBI) or regional irradiation and is a major component of the acute radiation syndrome. The purpose of this study was to identify novel radioprotectors and mitigators of the hematopoietic system.

Experimental design

High-throughput screening of small-molecule libraries was done using viability of a murine lymphocyte line as a readout with further validation in human lymphoblastoid cells. The selected compounds were then tested for their ability to counter TBI lethality in mice.

Results</

SUBMITTER: Kim K 

PROVIDER: S-EPMC2787903 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature