The chimpanzee Mhc-DRB region revisited: gene content, polymorphism, pseudogenes, and transcripts.

ABSTRACT: In humans, great apes, and different monkey species, the major histocompatibility complex (MHC) class II DRB region is known to display considerable copy number variation. The microsatellite D6S2878 has been shown to be a valuable marker for haplotyping the DR region in humans and macaque species. The present report illustrates that chimpanzee haplotypes also can be discriminated with this marker. The analyses resulted in the description of nine different region configurations, of which seven are present within the West African chimpanzee population studied. The region configurations vary in gene content from two up to five DRB genes. Subsequent cDNA sequencing increased the number of known full-length Patr-DRB sequences from 3 to 32, and shows that one to three Patr-DRB genes per haplotyp

SUBMITTER: de Groot NG 

PROVIDER: S-EPMC2788069 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature