Genome-wide association data reveal a global map of genetic interactions among protein complexes.

ABSTRACT: This work demonstrates how gene association studies can be analyzed to map a global landscape of genetic interactions among protein complexes and pathways. Despite the immense potential of gene association studies, they have been challenging to analyze because most traits are complex, involving the combined effect of mutations at many different genes. Due to lack of statistical power, only the strongest single markers are typically identified. Here, we present an integrative approach that greatly increases power through marker clustering and projection of marker interactions within and across protein complexes. Applied to a recent gene association study in yeast, this approach identifies 2,023 genetic interactions which map to 208 functional interactions among protein complexes. We show th

SUBMITTER: Hannum G 

PROVIDER: S-EPMC2788232 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature