Aging mice show a decreasing correlation of gene expression within genetic modules.

ABSTRACT: In this work we present a method for the differential analysis of gene co-expression networks and apply this method to look for large-scale transcriptional changes in aging. We derived synonymous gene co-expression networks from AGEMAP expression data for 16-month-old and 24-month-old mice. We identified a number of functional gene groups that change co-expression with age. Among these changing groups we found a trend towards declining correlation with age. In particular, we identified a modular (as opposed to uniform) decline in general correlation with age. We identified potential transcriptional mechanisms that may aid in modular correlation decline. We found that computationally identified targets of the NF-KappaB transcription factor decrease expression correlation with age. Finally,

SUBMITTER: Southworth LK 

PROVIDER: S-EPMC2788246 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature